Roger Federer has been knocked out of the US Open in the fourth round by world number 55 John Millman.
The 37-year-old Swiss had prioritised winning a sixth title at Flushing Meadows but was beaten 3-6 7-5 7-6 (9-7) 7-6 (7-3) in three hours 35 minutes.
It is the first time Federer has lost to a player ranked outside of the top 50 at the US Open.Australian Millman will play two-time champion Novak Djokovic in his first Grand Slam quarter-final on Wednesday.
Millman, 29, had never beaten a top-10 player before but suddenly found himself with five match points against arguably the greatest male player of all-time.
Maria Sharapova is out of the US Open after she was beaten 6-4 6-3 by Carla Suarez Navarro in the fourth round.
The five-time Grand Slam champion was broken three times in the first set and immediately at the start of the second.
Sharapova broke back in the third but dropped serve again before squandering two break points while trailing 4-2.
The 2006 champion was then broken in the final game of the match as 30th seed Suarez Navarro celebrated her 30th birthday with a shock victory.